Cortisol Level Related Glucose Intolerance in Adult with Obese Central
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Abstract
Obesity is associated with an increased risk of diseases, especially central obesity. Central obesity is a risk factor of glucose intolerance. Glucose intolerance is the beginning of diabetes mellitus. Many factors influence glucose intolerance. The aim of this study was to investigate the relationship between cortisol levels and some other factors related glucose intolerance. This study was a cross-sectional study from 12 high schools in Makassar. The analysis for this study was performed with 54 teachers. Characteristic samples, anthropometry, fasting blood glucose (FBG), cortisol were measured for all samples. Blood plasma glucose was measured from venous blood samples. Respondents were mostly female (85.2%), married (87%), bachelor’s degree (79,6%) and Buginesse (66.7%). The average age of respondents was 49.37 years. The results showed a significant relationship formula: between high cortisol levels in respondents who experienced glucose intolerance (p=0.043). Stress variables did not show a significant relationship, but the average score was higher in those who experienced glucose intolerance than those who had normal glucose. The frequency of consumption of carbohydrates, fats, proteins, and Body mass index (BMI) did not show a significant relationship with glucose intolerance. Cortisol levels are associated with glucose intolerance in adults with central obesity.
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Hasan, N., Hadju, V., Jafar, N., & Thaha, R. M. (2020). Cortisol Level Related Glucose Intolerance in Adult with Obese Central. Journal of Health Science and Prevention, 3(3S), 131–135. https://doi.org/10.29080/jhsp.v3i3S.299
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2. Zhao G, Ford ES, Li C, Tsai J, Dhingra S, Balluz LS. Waist circumference, abdominal obesity, and depression among overweight and obese US adults: National Health and Nutrition Examination Survey 2005-2006. BMC psychiatry. 2011;11(1):130.
3. Association AD. Standards of medical care in diabetes—2015 abridged for primary care providers. Clinical diabetes: a publication of the American Diabetes Association. 2015;33(2):97.
4. Alberti K, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120(16):1640-1645.
5. Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. Journal of the American College of Cardiology. 2012;59(7):635-643.
6. Shera AS, Basit A, Fawwad A, et al. Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in the Punjab Province of Pakistan. Primary care diabetes. 2010;4(2):79-83.
7. Raghupathy P, Antonisamy B, Fall CHD, et al. High prevalence of glucose intolerance even among young adults in south India. Diabetes Research and Clinical Practice. 2007/08/01/ 2007;77(2):269-279.
8. Jeppesen C, Bjerregaard P, Jørgensen ME. Dietary patterns in Greenland and their relationship with type 2 diabetes mellitus and glucose intolerance. Public health nutrition. 2014;17(2):462-470.
9. Walsh EI, Jacka FN, Butterworth P, Anstey KJ, Cherbuin N. The association between Western and Prudent dietary patterns and fasting blood glucose levels in type 2 diabetes and normal glucose metabolism in older Australian adults. Heliyon. 06 2017;3(6):e00315.
10. Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism. Current opinion in pharmacology. 2009;9(6):787-793.
11. Siddiqui A, Madhu S, Sharma S, Desai N. Endocrine stress responses and risk of type 2 diabetes mellitus. Stress. 2015;18(5):498-506.
12. Reynolds RM, Labad J, Strachan MW, et al. Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study. The Journal of Clinical Endocrinology & Metabolism. 2010;95(4):1602-1608.
13. GARBELLOTTO GI, REIS FJ, FEOLI AMP, Et Al. SALIVARY CORTISOL AND METABOLIC SYNDROME COMPONENT’S ASSOCIATION. ABCD. Arquivos Brasileiros De Cirurgia Digestiva (São Paulo). 2018;31(1).
14. Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. The Journal of Clinical Endocrinology & Metabolism. 2002;87(12):5587-5593.
15. Notarianni E. Cortisol: Mediator of association between Alzheimer’s disease and diabetes mellitus? Psychoneuroendocrinology. 2017;81:129-137.
16. Chen S, Zhang Q, Dai G, et al. Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis. Springer; 2016.
17. Poongothai S, Anjana RM, Pradeepa R, Ganesan A, Umapathy N, Mohan V. Prevalence of depression in relation to glucose intolerance in urban south Indians—the Chennai Urban Rural Epidemiology Study (CURES-76). Diabetes technology & therapeutics. 2010;12(12):989-994.
18. Hirokawa K, Ohira T, Nagayoshi M, et al. Occupational status and job stress in relation to cardiovascular stress reactivity in Japanese workers. Preventive Medicine Reports. 2016/12/01/ 2016;4:61-67.
19. Papaetis GS, Papakyriakou P, Panagiotou TN. Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Archives of medical science: AMS. 2015;11(3):463.
20. Sefidbakht S, Johnson-Down L, Young TK, Egeland GM. High protein and cholesterol intakes associated with emergence of glucose intolerance in a low-risk Canadian Inuit population. Public Health Nutrition. 2015;19(10):1804-1811.